When you are looking for an hotel in Venice you should remember first that the area of Venice is quite large, including islands, mainland and the lagoon. You can decide to stay into the heart of the city, outside the centre or in the mainland. It depends on how much time are you going to spend in Venice and how much you want to spend.
The historic centre is divided into six districts (called Sestieri), in detail:
• San Marco
• San Polo
• Santa Croce
The main tourist areas are around San Marco Square, Piazzale Roma and the train station Santa Lucia. These areas are always filled of tourists and it’s easy to understand that are noisy and chaotic. From the other side they are ideal for short trips because help you make the most of your time.
If your intention is having a romantic stay, far from crowd and noise, you should consider to choose a quieter location which might involve more walking or ferry trips. In this case remember that the only way to travel in Venice is on foot or by boat, so before you book check the location of the hotel and understand how far the accommodation is from the nearest vaporetto stop. Coming back home at night after a many-hours-walk day is surely pleasant but can also be exhausting…
So if you are planning a high-efficiency stay search your hotel in the train station area or near St. Mark Square. It could be Santa Croce east, San Polo or Cannaregio south.
If you instead are planning a romantic and quite stay consider Dorsoduro district or Castello west. For nightlife choose Rialto area or the heart of Dorsoduro, full of students.